Table II.

neutrophil subpopulations in diseases

N1/N2	Disease Model	Subjects	Key Findings	References
N1	Tuberculous pleurisy	Guinea pigs	TGF-β neutralization increases neutrophils in pleural exudate.	Allen et al., 2008 [69]
N1	Tumor	Mouse	TGF-β blockade reduces tumor metastasis.	Kazemfar et al., 2009 [70]
N2	NA	Human	Regulatory T cells inhibit neutrophils survival and their ROS and cytokine production, which is confirmed at least partially mediated by and IL-10.	Lewkowicz et al., 2006 [65]
N2	NA	Human	TGF-β1 suppresses neutrophil degranulation to prevent them from initiating an inflammatory response.	Shen et al., 2007 [64]
N2	Stroke	Mouse	PPAR-γ activation with rosiglitazone induces “N2” neutrophils.	Cuartero et al. 2013 [63]
N/N2	Tumor	Mouse	Blockade of TGF-β promotes tumor-associated neutrophils with an anti-tumor phenotype, which is referred as N1. TGF-β in tumor microenvironment induces a pro-tumor neutrophils, N2.	Fridlender et al., 2009 [62]

NA, not available