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. 2014 Oct 20;23(12):1650–1666. doi: 10.1002/pro.2552

Figure 2.

Figure 2

TP53 sequences from different species and variations in their amino acids. Some homology-based methods would predict that the human sequence would tolerate a substitution of alanine to aspartic acid or to cysteine at the highlighted position. Other methods account for the conservation of a position, concluding that the highlighted position would likely tolerate more substitutions than other positions.