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The decrease in the temperature of the thermally induced midpoint of structural unfolding, Tm, of moPrP (121–231) induced by increasing concentration of different nucleic acids at pH 5. The protein concentration was kept constant (20 µM) and nucleic acid concentrations were varied. The results show increased destabilization with increasing concentrations of the nucleic acids at pH 5. The maximum extent of the decrease in the Tm values depends upon the composition of the nucleic acids.
