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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Insect Biochem Mol Biol. 2014 Sep 23;54:98–105. doi: 10.1016/j.ibmb.2014.09.006

Fig. 8. Model of ETH signal transduction in CA.

Fig. 8

Binding of ETH to the AeaETH-receptor results in increases of IP3 synthesis and IP3R-dependent release of Ca2+ from the ER. Ca2+ increases JHAMT activity and JH biosynthesis. ETH: ecdysis triggering hormone; GPCR: G-protein coupled receptor; IPI2: phosphatidylinositol 3,4 biphosphate; IP3: inositol triphosphate; IP3R: Inositol triphosphate receptor; PLC: phospholipase C; PKC: phosphokinase C; DAG: diacylglycerol; SOC: store-operated Ca2+ entry channel; ER: endoplasmic reticulum; JH: juvenile hormone.