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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Clin Cancer Res. 2014 Oct 10;20(23):5898–5907. doi: 10.1158/1078-0432.CCR-13-2437

Figure 1.

Figure 1

EGFR signaling pathways and receptor cross-talk. Activation of EGFR propagates downstream pro-growth signals through the MAPK pathway (RAS-RAF-MEK-ERK) and PI3K-AKT-mTOR pathway. Targets for potential combinatorial therapeutic strategies to overcome resistance are noted.