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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: J Allergy Clin Immunol. 2014 Jun 13;134(5):1153–1162. doi: 10.1016/j.jaci.2014.04.011

Figure 3. Haplotype analysis of the FADS2 locus.

Figure 3

(a) Haplotype structure: Haplotype frequencies observed in at least 1% of CAMP subjects are listed to the right of each haplotype sequence. Dots indicate the allele present in haplotype H1 – the most common haplotype. The asthma-associated rs968567 T allele is unique to, and uniquely tags, haplotype 2 (H2, boxed in blue), observed at 18.1% frequency. (b) Haplotype-based eQTL analysis: H2 demonstrates strong association with increased FADS2 expression (p<10−10), while haplotype 1 (H1, frequency 31.4%) is associated with low FADS2 expression. Others (H3-H8) showed intermediate levels of FADS2 expression.