Table II.
Constituent fatty acids of the red blood cell membrane, by O3I tertiles
| Fatty Acid, % cell membrane | All patients (N= 111) | O3I tertile I (N= 37) | O3I tertile II (N= 37) | O3I tertile III (N= 37) | P-valuea |
|---|---|---|---|---|---|
| Ω-3 Fatty acids, total | 8 ± 2 | 6 ± 0.5 | 7 ± 1 | 10 ± 2 | <.001 |
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| |||||
| Alpha-linolenic C18:2n3 | 0.1 ± 0.07 | 0.1 ± 0.04 | 0.1 ± 0.05 | 0.1 ± 0.1 | .3 |
| Eicosapentaenoic C20:5n3 | 0.6 ± 0.5 | 0.4 ± 0.1 | 0.5 ± 0.2 | 1 ± 1 | <.001 |
| Docosapentaenoic-n3 C22:5n3 | 3 ± 1 | 3 ± 0.4 | 3 ± 0.4 | 3 ± 0.7 | <.001 |
| Docosahexaenoic C22:6n3 | 4 ± 1 | 3 ± 0.4 | 4 ± 0.3 | 6 ± 1 | <.001 |
| Ω-6 Fatty acids, total | 35 ± 3 | 37 ± 2 | 36 ± 1 | 33 ± 3 | <.001 |
|
| |||||
| Linoleic C18:2n6 | 11 ± 2 | 11 ± 2 | 11 ± 1 | 10 ± 2 | .07 |
| Gamma-linolenic C18:3n6 | 0.1 ± 0.03 | 0.1 ± 0.03 | 0.1 ± 0.04 | 0.1 ± 0.02 | .01 |
| Eicosadienoic C20:3n6 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 | .4 |
| Dihomo-g-linolenic C20:3n6 | 2 ± 0.4 | 2 ± 0.4 | 2 ± 0.4 | 2 ± 0.5 | .9 |
| Arachidonic C20:4n6 | 17 ± 2 | 18 ± 1 | 18 ± 1 | 16 ± 2 | .01 |
| Docosatetraenoic C22:4n6 | 5 ± 1 | 5 ± 1 | 5 ± 1 | 4 ± 1 | <.001 |
| Docosapentaenoic C22:5n6 | 1 ± 0.3 | 1 ± 0.2 | 1 ± 0.2 | 1 ± 0.3 | .003 |
| Saturated fat, total | 41 ± 1 | 41 ± 1 | 41 ± 1 | 41 ± 1 | 1 |
|
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| Mysteric C14:0 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 | .8 |
| Palmitic C16:0 | 22 ± 1 | 22 ± 1 | 22 ± 1 | 22 ± 1 | .9 |
| Stearic C18:0 | 18 ± 1 | 18 ± 1 | 18 ± 1 | 18 ± 1 | .7 |
| Arachidic C20:0 | 0.1 ± 0.03 | 0.1 ± 0.04 | 0.1 ± 0.03 | 0.1 ± 0.03 | .2 |
| Behenic C22:0 | 0.1 ± 0.1 | 0.1 ± 0.1 | 0.1 ± 0.1 | 0.2 ± 0.1 | .4 |
| Lignoceric C24:0 | 0.3 ± 0.2 | 0.3 ± 0.2 | 0.3 ± 0.1 | 0.4 ± 0.2 | .1 |
| Trans fat, total | 1 ± 0.4 | 1 ± 1 | 1 ± 0.3 | 1 ± 0.3 | .01 |
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| Palmitelaidic C16:1n7t | 0.1 ± 0.04 | 0.1 ± 0.04 | 0.1 ± 0.04 | 0.1 ± 0.04 | .8 |
| Elaidic C18:1t | 1 ± 0.4 | 1 ± 0.5 | 1 ± 0.3 | 1 ± 0.2 | .01 |
| Linoelaidic C18:2n6t | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 | .2 |
|
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| Monounsaturated fat, total | 15 ± 1 | 15 ± 1 | 14 ± 1 | 15 ± 1 | .04 |
| Palmitoleic C16:1n7 | 0.3 ± 0.2 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 | .2 |
| Oleic C18:1n9 | 14 ± 1 | 14 ± 1 | 13 ± 1 | 14 ± 1 | .07 |
| Eicosenoic C20:1n9 | 0.2 ± 0.05 | 0.2 ± 0.05 | 0.2 ± 0.04 | 0.2 ± 0.06 | .03 |
| Nervonic C24:1n9 | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.3 ± 0.1 | 0.4 ± 0.2 | .04 |
a
p-value calculated from ANOVA for continuous variables; Mean ± SD presented