Figure 1.
Establishment of the intraneural vascular plexus and a functional BBB during mouse embryogenesis. (A) Semithin section of embryonic mouse neocortex at E10 showing the intraneural and parts of the surrounding perineural domain (B) neuroepithelial cells surround a primitive capillary (white arrow) containing a red blood cell (asterisk). Murine E13 (C) and E17 (D) embryos microperfused with 0.5% Trypan blue solution. After fixation specimens were cut medially and photographed. Arrowhead indicates and enlarged area depicts stained choroid plexus (Bauer et al., 1993, 1995).