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. 2014 Dec 3;8:392. doi: 10.3389/fnins.2014.00392

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Copyright © 2014 Bauer, Krizbai, Bauer and Traweger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TJ-MAGUKS are membrane-associated adaptor proteins assembling the tight junction plaque. (A) ZO-1, ZO-2, and ZO-3 are multi-domain proteins composed of three PDZ domains, one SH3 and a catalytically inactive GUK domain. Next to these MAGUK-related domains, ZO proteins also contain various ZO-specific unique (U) and proline-rich (P) regions. ZU5 is a region found in ZO-1 and Unc5-like netrin receptors. (B) ZO-1 and ZO-2 are at the basis of large protein assemblies containing structural and signaling molecules. Shown are proteins that have been demonstrated to interact with ZO-1 or ZO-2 in epithelial and endothelial cells. Gene symbols according to the H.G.N.C. nomenclature are indicated.

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