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. 2014 Dec 3;8:410. doi: 10.3389/fncel.2014.00410

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Copyright © 2014 Stahl, Schilling, Soba, Rupp, Hartmann, Wagner, Merdes, Eggert and Kins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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APP processing modulates synaptic function. Schematic representation of APP trans-dimerization and its synaptic function. (A) Enhanced synaptic activity leads to increased APP processing and less intact full length APP available for trans-dimerization at the synapse. The secreted cleavage product sAPPα and Aβ might bind different receptors at the pre- and postsynaptic sites modulating neurotransmission and/or synapse formation. (B) Under conditions of low synaptic activity less APP processing occurs and more full length APP will be available for trans-synaptic dimerization.