Table 2.
Patient ID | Reovirus RNA | Reovirus protein | p38 | Caspase-3 | Cycle of treatment |
---|---|---|---|---|---|
A | 36% | 9% | 94% | 1% | 8 |
B | 100% | 14% | 78% | ND | 2 |
C | 100% | 11% | 98% | 0.3% | 1 |
D | 100% | 3% | 19% | 1% | 1 |
G | 40% | 1% | 45% | 0% | 1 |
H | 100% | 0% | 99% | ND | 4 |
I | 20% | ND | ND | ND | 5 |
Immunohistochemical analysis of 7 evaluable patient samples; co-expression analyses included CD138+, reoviral RNA, capsid protein, p38, and caspase-3. Abbreviations: Reovirus RNA = reoviral RNA/CD138+ cells post-treatment; Reovirus protein = reoviral protein/CD138+ cells post-treatment; p38/CD138+ = p38 pre-treatment cells; caspase-3 = caspase-3 post-treatment.