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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Acta Biomater. 2014 Sep 4;10(12):4939–4946. doi: 10.1016/j.actbio.2014.08.032

Figure 5.

Figure 5

Netrin-1-immobilized scaffolds increased polarized RGC axon growth toward the scaffold center.

When compared to RGCs cultured on control scaffolds without immobilized Netrin-1 (A–C), RGCs cultured on Netrin-1-immobilized scaffolds (D–F) showed a significant shift from bipolar (arrow heads) to polarized cells, as well as an increase in RGCs with polarized growth toward the scaffold center (thick closed arrows); some RGCs polarized away from the center (thin open arrows). In both control scaffolds (C) and Netrin-1-immobilized scaffolds (F) RGC neurites were unable to extend across the central point of the scaffold (white dashed circle). (* p < 0.05 by one way ANOVA with post hoc analysis by Fisher’s LSD test, NS: not significant) Scale bars: A and D 300 μm; B and E 100 μm; C and F 500 μm.