Table 3.
Comparison of survival estimates per 1% methylation of the 7 CpG loci identified from the oral rinse Infinium HumanMethylation450 BeadArray to the corresponding estimates from the pyrosequencing data set.
| Locus ID | Infinium HumanMethyaltion450 BeadArray
|
Pyrosequencing
|
||
|---|---|---|---|---|
| Crude HR (95% CI) | Adjusted HR* (95% CI) | Crude HR (95% CI) | Adjusted HR* (95% CI) | |
| cg02319972 | 0.87 (0.82, 0.92) | 0.85 (0.80, 0.91) | 1.00 (0.92, 1.09) | 1.01 (0.91, 1.11) |
|
| ||||
| cg03784083 | 0.74 (0.65, 0.85) | 0.70 (0.60, 0.82) | 0.95 (0.87, 1.04) | 0.96 (0.82, 1.12) |
|
| ||||
| cg15740054 | 3.65 (2.09, 6.32) | 6.31 (3.05, 13.05) | 1.00 (0.76, 1.33) | 0.91 (0.66, 1.24) |
|
| ||||
| cg18928362 | 1.72 (1.32, 2.25) | 1.60 (1.22, 2.12) | 0.84 (0.21, 3.40) | 0.36 (0.07, 1.77) |
|
| ||||
| cg21022792 | 0.85 (0.79, 0.92) | 0.84 (0.77, 0.91) | 0.94 (0.76, 1.15) | 0.78 (0.61, 1.01) |
|
| ||||
| cg21702497 | 1.48 (1.23, 1.79) | 1.54 (1.20, 1.98) | 1.00 (0.17, 5.79) | 0.79 (0.09, 7.21) |
|
| ||||
| cg25914931 | 3.24 (1.86, 5.66) | 4.45 (2.17, 9.15) | 1.03 (0.17, 6.23) | 0.53 (0.08, 3.51) |
*
Adjusted for age, gender, smoking pack-years, HPV16 and stage at diagnosis