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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Trends Genet. 2014 Oct 8;30(12):521–528. doi: 10.1016/j.tig.2014.09.004

Figure 2. LacI protein architecture and long-range allosteric connections.

Figure 2

Structure of a LacI dimer bound to DNA is shown on the left side, key regions highlighted in different colors. The dotted lines on the right side show long-range connection between four mutations (M42, A133, D149 and S151) that rescue allostery in Y282D.