Table 2.
Age, body mass index, serum leptin levels (ng/mL), and ratio leptin/BMI of controls and therapy-naïve patients with clinically isolated syndrome suggestive of MS (CIS) or relapsing-remitting MS (RRMS). Mean values ± SD. Evaluation by ANOVA with age and BMI as covariates for leptin and age as covariate for leptin/BMI ratio.
| Group | N | Age | BMI | Leptin | Leptin/BMI |
|---|---|---|---|---|---|
| Males | |||||
| Controls | 30 | 36.8 ± 8.1 | 25.7 ± 3.6 | 5.6 ± 3.5 | 0.21 ± 0.10 |
| Patients, all | 35 | 33.8 ± 6.3 | 25.4 ± 3.2 | 4.7 ± 1.6 | 0.18 ± 0.05 |
| F/P | 1.92/.17 | 1.64/.21 | |||
| CIS | 21 | 34.7 ± 6.2 | 26.1 ± 3.7 | 4.8 ± 1.8 | 0.18 ± 0.06 |
| RRMS | 14 | 32.6 ± 6.3 | 24.4 ± 1.9 | 4.5 ± 1.5 | 0.18 ± 0.05 |
| F/P | 1.26/.26 | 0.84/.44 | |||
| Females | |||||
| Controls | 43 | 33.6 ± 7.8 | 24.1 ± 3.8 | 10.9 ± 7.6 | 0.43 ± 0.25 |
| Patients, all | 54 | 32.9 ± 6.2 | 22.9 ± 4.3 | 10.6 ± 8.1 | 0.44 ± 0.25 |
| F/P | 1.29/.26 | 0.01/.92 | |||
| CIS | 32 | 33.3 ± 6.1 | 23.3 ± 4.4 | 9.2 ± 8.5 | 0.36 ± 0.26 |
| RRMS | 22 | 32.3 ± 6.5 | 22.3 ± 4.3 | 12.6 ± 7.2 | 0.54 ± 0.20 |
| F/P | 6.57/.002 | 3.54/.033 | |||
| Females, planned comparisons | |||||
| Controls versus CIS, F/P | 0.31/.58 | 1.48/.23 | |||
| Controls versus RRMS, F/P | 9.53/.003 | 2.98/.09 | |||
| CIS versus RRMS, F/P | 11.70/.001 | 7.07/.009 |