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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Mol Aspects Med. 2014 Jul 8;0:1–116. doi: 10.1016/j.mam.2014.05.001

Figure 3.

Figure 3

Structure of the HMGB1 protein. (A) HMGB1 has two DNA-binding domains (A and B box) and an acidic C-terminal tail. (B) Helical secondary structure of A and B box domains (Thomas, 2001). (C) Intramolecular disulfide bond in the Adomain of HMGB1 (Wang et al., 2013e).