Table 2.
Experimental Groups
| Experiment | N | Purpose of Study* | Control† | GA | GA + GL | GL | Buffer + GL | Buffer | GA Soaked | Weeks Followed |
|---|---|---|---|---|---|---|---|---|---|---|
| Glaucoma Experiment 1 | 81 | Effect of GA on glaucoma-induced damage | 40 | 41 | 7 | |||||
| Glaucoma Experiment 2 | 50 | Effects of GA on glaucoma damage and scleral thickness | 10 | 20 | 20 | 7 | ||||
| IOP Calibration | 6 | Quality of IOP readings on Injected eyes | 3 | 3 | 7 | |||||
| Retina Histology | 5 | Effect of GA on retinal tissue | 5 | 7 | ||||||
| ERG | 5 | Effect of GA on photopic and scotopic retinal function | 5 | 7 | ||||||
| AGE | 37 | Effect of GA on cross-linking | 5 | 13 | 14 | 5 | 7 | |||
| FRAP | 39 | Effect of GA on sclera permeability | 19 | 10 | 10 | 7 | ||||
| Inflation/Stiffness | 157 | Effect of GA on stress/strain | 28 | 23 | 31 | 20 | 28 | 26 | 7 |
*
Animals received treatment on le4 eyes, while right eyes were untreated.
†
Control animals were bilateral naïve controls.
GA = glyceraldehyde; GL = glaucoma induced via bead model. Weeks Followed = 7 weeks total (1 week of “stiffening” treatment and 6 weeks of glaucoma treatment)