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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Trends Cell Biol. 2014 Oct 7;24(11):616–618. doi: 10.1016/j.tcb.2014.09.004

Figure 1. Chromatin dynamics during HR at actively transcribed regions.

Figure 1

Histone modifications that mark open chromatin are deposited during transcription. After double-strand break (DSB) occurs at these regions, the pre-existing marks of open chromatin recruit repair machinery and remodeling complexes to the DSB to rapidly mediate chromatin relaxation. This is followed by prolonged gradual compaction of the chromatin, along with the deposition of histone marks associated with closed chromatin.