Table 1.
Gene | Acceptor Substrate | Donor Substrate | Subcellular Localization | Effect on Notch | |
---|---|---|---|---|---|
POFUT1/Ofut1 | EGF | GDP-Fuc | ER | Essential | |
Lunatic fringe | Fuc-EGF | UDP-GlcNAc | Golgi | Notch activation | |
Manic fringe | Fuc-EGF | UDP-GlcNAc | Golgi | Notch activation | |
Radical fringe | Fuc-EGF | UDP-GlcNAc | Golgi | Notch activation | |
POGLUT1/Rumi | EGF | UDP-Glc | UDP-Xyla | ER | Essential |
GXYLT1 | Glc-EGF | UDP-Xyl | Unknown | Inhibitory | |
GXYLT2 | Glc-EGF | UDP-Xyl | Unknown | Inhibitory | |
XXYLT1 | Xyl-Glc-EGF | UDP-Xyl | ER | Inhibitory | |
EOGT1 | EGF | UDP-GlcNAc | ER | ? |
POGLUT1/Rumi can utilize UDP-Xyl when acceptor substrates have a diserine-motif (C-X-S-S-P/A-C) within the O-glucose consensus sequence.