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. Author manuscript; available in PMC: 2015 Oct 17.
Published in final edited form as: Biochem Biophys Res Commun. 2014 Jun 6;453(2):235–242. doi: 10.1016/j.bbrc.2014.05.115

Table 1.

Mammalian glycosyltransferases that preferentially modify EGF repeats.

Gene Acceptor Substrate Donor Substrate Subcellular Localization Effect on Notch
POFUT1/Ofut1 EGF GDP-Fuc ER Essential
Lunatic fringe Fuc-EGF UDP-GlcNAc Golgi Notch activation
Manic fringe Fuc-EGF UDP-GlcNAc Golgi Notch activation
Radical fringe Fuc-EGF UDP-GlcNAc Golgi Notch activation
POGLUT1/Rumi EGF UDP-Glc UDP-Xyla ER Essential
GXYLT1 Glc-EGF UDP-Xyl Unknown Inhibitory
GXYLT2 Glc-EGF UDP-Xyl Unknown Inhibitory
XXYLT1 Xyl-Glc-EGF UDP-Xyl ER Inhibitory
EOGT1 EGF UDP-GlcNAc ER ?
a

POGLUT1/Rumi can utilize UDP-Xyl when acceptor substrates have a diserine-motif (C-X-S-S-P/A-C) within the O-glucose consensus sequence.