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. 2014 Jun 3;8(8):1419–1428. doi: 10.1016/j.molonc.2014.05.012

Figure 2.

Figure 2

AURKA overexpression induces STAT3 transcriptional activity. (A) FLO‐1 cells were transfected with pcDNA or AURKA in combination with STAT3 luciferase reporter plasmids, and STAT3 luciferase reporter activity was measured. The data indicate that AURKA can enhance STAT3 transcriptional activity. (B) Knockdown of endogenous AURKA decreases STAT3 luciferase reporter activity, whereas re‐introducing AURKA rescued the STAT3 activity levels. (C) AGS cells were transfected with pcDNA or AURKA in combination with STAT3 luciferase reporter plasmids, and STAT3 luciferase reporter activity was measured. The data indicate that AURKA can enhance STAT3 transcriptional activity. (D) MKN45 cells were transfected with shScramble or shAURKA in combination with STAT3 luciferase reporter plasmids, and STAT3 luciferase reporter activity was assessed. The data show that knockdown of endogenous AURKA decreases STAT3 transcriptional activity in a dose‐dependent fashion.