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AURKA pharmacological inhibition decreases STAT3 phosphorylation and reduces cell survival. FLO‐1 (A) and AGS (B) cells treated with MLN8237 (0.5 μM) for 72 h and subjected to Western blot analysis. Data indicated down‐regulation of p‐STAT3 (Tyr705) and STAT3 targets, BCL2 and MCL1, protein expression. FLO‐1 (C) and AGS (D) cells treated with vehicle or MLN8237 (0.5 μM) for 24 h and then cultured in fresh media for 10 days. Graphs show colonies quantitative data (right panels).
