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AURKA regulates JAK2 expression. (A) Silencing AURKA (siAURKA) in FLO‐1 cells led to decreased JAK2 at both protein and mRNA levels. (B) FLO‐1 cells stably overexpressing AURKA showed an increase in JAK2 at both protein and mRNA levels. (C, D) Inhibition of JAK2 using pharmacologic inhibitor (AZD1480) (C) or genetic knockdown JAK2 using siRNA (siJAK2) (D) abrogated AURKA‐induced phosphorylation of STAT3 in FLO‐1 cells.
