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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Neurobiol Dis. 2014 Oct 2;73:106–117. doi: 10.1016/j.nbd.2014.09.017

Fig. 1. Characterization of the epileptic phenotype of DS/129 mice.

Fig. 1

(A and B) Induction of seizures by increasing body core temperature. (A) Percentage of P21 mice remaining free of behavioral seizures (SZ) versus body core temperature, fitted with a sigmoid (line). WT mice of either strain do not have seizures at the tested temperatures. DS/129, n=11, DS/B6 n=4. (B) Percentage of mice remaining free of behavioral myoclonic seizures. (C) Representative intracranial EEG activity of DS/129 at P28. The depicted seizure was recorded at 40 °C. (D) Contextual fear conditioning test. WT/129 and DS/129 display similar freezing behavior during training and when reintroduced to the chamber 0.5 and 24 h later. n=14 for each genotype. (E) Three-chamber experiment. WT/129 mice spend more time in the chamber housing a stranger mouse (mouse) than the chamber housing an empty cage (object) or in the connecting chamber (center). DS/129 mice have no preference for either chamber. n=10 for each genotype.