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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Neurobiol Dis. 2014 Oct 2;73:106–117. doi: 10.1016/j.nbd.2014.09.017

Fig. 3. Firing properties of CA1 pyramidal neurons are not changed by the DS mutation.

Fig. 3

(A) Representative APs of CA1 pyramidal neurons induced by 10 ms depolarizing current pulses through the patch pipette at rheobase. (B) Mean AP rheobase and threshold. (C) Average firing frequency of CA1 pyramidal cells in response to 1 s depolarizing current injection at the indicated intensity. n=5–8. (D–F) Percent successful APs in pyramidal neurons in response to 10 ms, depolarizing current pulses at 1 Hz (D), 10 Hz (E) and 50 Hz (F). 100% indicates one successful AP in every trial; values > 100% indicate that 2 APs were evoked during the 10 ms depolarization. n=5–7.