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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: J Neuroimmunol. 2014 Aug 27;276(0):180–186. doi: 10.1016/j.jneuroim.2014.08.618

Fig. 3. IL-7 stimulation induces a higher enhancement of cytotoxicity in NK cells of MS patients.

Fig. 3

NK cells from MS patients and HCs were purified with magnetic sorting and cultured with or without IL-7 for 72 hours. Cytotoxic activity was measured by the lactate dehydrogenase (LDH)-based assay. Three ratios [effector: target cells (E: T)] were tested and lysis (in %) is indicated. Compared to HC, NK cells from MS patients cultured with IL-7 show a higher enhancement of cytotoxicity effects at effector to target ratio of 2.5:1, 5:1 and 10:1. Data from five independent experiments were statistically analyzed. 5 relapsing remitting patients, 3 secondary progressive and 2 primary progressive patients were included in this study. 10 HC were relatives of MS patients. *p < 0.05; **p < 0.01.