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. Author manuscript; available in PMC: 2015 Dec 1.

Published in final edited form as: Clin Cancer Res. 2014 Oct 7;20(23):6006–6015. doi: 10.1158/1078-0432.CCR-14-1415

Images and graphs of a pIR case with (a) DOST images prior, during and after NAC. In (b), axial post contrast subtraction MRI before NAC shows the index invasive breast cancer (upper image) in the lateral right breast at 9:00 o’clock and measuring 5.4 × 3.4 × 5.2 cm, and a subpectoral lymph node metastasis (lower image) at 12:00 o’clock measuring 2.5 × 1.9 × 3.0 cm. The yellow arrows show the dominant tumors in each image. Additionally, rim enhancing skin metastases exist overlying the index tumor at 9:00 o’clock (arrowheads). In (c),(d) and (e), Hb_T, StO₂ and H₂O are graphed for different time points.

Images and graphs of a pIR case with (a) DOST images prior, during and after NAC. In (b), axial post contrast subtraction MRI before NAC shows the index invasive breast cancer (upper image) in the lateral right breast at 9:00 o’clock and measuring 5.4 × 3.4 × 5.2 cm, and a subpectoral lymph node metastasis (lower image) at 12:00 o’clock measuring 2.5 × 1.9 × 3.0 cm. The yellow arrows show the dominant tumors in each image. Additionally, rim enhancing skin metastases exist overlying the index tumor at 9:00 o’clock (arrowheads). In (c),(d) and (e), Hb_T, StO₂ and H₂O are graphed for different time points.