Table 2.

Assessment of the 3D localization of functional annotations in S. cerevisiae

Functional annotation	MPED q-values		Contact enrichment q-values
	HindIII	EcoRI	HindIII	EcoRI
Centromeres	4.0e-04	3.7e-04	2.8e-03	5.6e-03
Long terminal repeats	4.0e-04	3.7e-04	2.8e-03	1.9e-02
Telomeres	0.86 ↓	0.13 ↓	5.0e-02	5.6e-03

MPED: the median of pairwise Euclidean distances in the 3D reconstruction. Contact enrichment: enrichment of dichotomized “close” pairs in the Hi-C contact data. Bold indicates q-value <0.05. Down arrow indicates dispersion (otherwise co-localization). Functional annotations are included if they were significant for both restriction enzyme libraries (HindIII and EcoRI) in either analysis.