Table 1.
Significant copy number variation (CNVs) regions detected by array-CGH
| Cytoband # | Samples | Start | Stop | Length (pb) | Event | N° | Gene ID | |
|---|---|---|---|---|---|---|---|---|
| Blood | Tumor | |||||||
| 9p12-p13.1 | Twin-1b | 38.944.256 | 40.498.819 | 1554563 | Loss | 7 | CNTNAP3, SPATA31A1, SPATA31A2, ZNF658B, LOC653501, DQ586551 and CNTNAP3B | |
| Twin-2b | ||||||||
| 10p15.3-p15.2 | Twin-1 t | 1,056,859 | 3,168,906 | 2112047 | Loss | 18 | ADARB2, ADARB2-AS1, AK097474, AK127347, AX748285, IDI1, IDI2, IDI2-AS1, PFKP, WDR37* | |
| Twin-2 t | ||||||||
| 12p12.3-p11.1 | Twin-1 t | 15.161.204 | 34.278.525 | 19117321 | Gain | 126 | PLCZ1, CAPZA3, CASC1, KRAS, ASUN, PPFIBP1, DDX11, MANSC4, KLHL42, PTHLH* | |
| Twin-2 t | ||||||||
| 12p13.33- p12.3 | Twin-1 t | 0 | 14.900.955 | 14900955 | Gain | 351 | ACRBP, AKAP3, CCND2, DDX47, LRP6, NANOG, YBX3, CACNA1C, FGF6, FKBP4* | |
| Twin-2 t | ||||||||
| 13q21.1-q21.2 | Twin-1 t | 58.321.428 | 60.493.818 | 2172390 | Loss | 6 | AK097816, BC032915, CR618830, DIAPH3, TDRD3 and DIAP3 | |
| Twin-2 t | ||||||||
| 15q11.1-q11.2 | Twin-1 t | 20.335.887 | 23.044.681 | 2708794 | Loss | 140 | SNORD116I, SNORD115, SNORD107, SNORD64, MAGEL2, NDN, SNURF, PAR-SN, PAR5, SNORD108* | |
| Twin-2 t | ||||||||
| Xq27.3 | Twin-2b | Twin-2 t | 144.344.622 | 145.204.327 | 859.706 | Gain | 9 | SLITRK2, TMEM257, MIR892C, MIR890, MIR888, MIR892A, MIR892B, MIR891B and MIR891A |
| Xq28 | Twin-1b | Twin-1 t | 150.522.209 | 153.914.671 | 3.392.463 | Gain | 7 | MAGEA2, MAGEA2B, FATE1, LAGE3, CTAG1B, CTAG1A and CTAG2 |
Legend: #: It was found only novel CNVs in the blood and tumor samples from monozygotic twins (DGV and Brazilian Database). *More than 10 genes were mapped in this representative chromosome region. The complete gene list is deposited in Gene Expression Omnibus (GEO) database (www.ncbi.nlm.nih.gov/geo/). Accession number: GSE62779.