. Author manuscript; available in PMC: 2015 Nov 1.

Published in final edited form as: Trends Cell Biol. 2014 Aug 4;24(11):686–694. doi: 10.1016/j.tcb.2014.07.001

Table 1.

Chromatin features in aging and cancer

	Aging	Cancer
DNA Methylation
DNA hypo-methylation	↑LINE and SINE regions ^16–21	↑LINE and SINE regions^{13,19,24–26}
DNA hyper-methylation	↑CGIs ^{20–21, 33, 35}	↑ CGIs ^5,14,34–36
Histones modifications
H4K16ac	↓ in vitro in aged cycling human fibroblasts⁵²	↓various cancers⁵⁵
H4K20me3	↓ in vitro in aged cycling human fibroblasts⁵² ↑ in vivo in livers and kidneys of old rats⁷⁸ ↑ Hutchinson-Gilford Progeria cells⁷⁷	↓various cancers^{55, 74} ↓ rats model⁷³
H3K9ac	↑ in vitro in aged cycling human fibroblasts⁵²	↑ lung cancer⁸¹ ↓ breast cancer⁸⁰
H3K4me3	↑ in vitro in aged cycling human fibroblasts⁵²	↓ breast cancer¹⁴¹ ↑ glioblastoma¹³⁶, renal cell carcinomas¹³⁷
H3K9me3	↓ in vitro in aged cycling human fibroblasts⁵²	↑ humans⁹¹ ↓ pancreatic carcinomas¹³⁸
H3K27me3	↓ Hutchinson-Gilford Progeria cells⁷⁷ ↓ senescent cells⁹⁹	↑ esophageal squamous cell carcinoma¹³⁹ ↓ pediatric high-grade gliomas¹⁰²
LncRNA
HOTAIR	ND	↑ breast¹¹⁴
HOTTIP	ND	↑ liver, leukemia ^{116, 117}
CTBP1-AS	ND	↑ prostate¹¹⁸
ANRASSF1	ND	↑ breast, prostate¹¹⁹
XIST	↓ senescence¹²²	ND
MALAT1	↓ senescence¹²²	↑ various cancers¹⁴⁰
SAL-RNA1	↓ senescence¹²²	ND
ANRIL	↓ senescence¹²⁶	↑ prostate, leukemia ^126–127

ND: not determined; Red: reduction of indicated feature; Green: increase of indicated feature