Table 3. Up- and down-regulated proteins found in altered spots of our study, together with the values of their oscillation in expression level.

Spot	Protein	Fold Change	Reference
	identified	(−/+)
		wt vs He/wt vs Ho
a	Heat Shock Protein −70	+1.44a/+2.5a	58,59
b	Phosphoglycerate mutase 1	−1.35b/−2.04b	33
c	α-enolase	+2.35a/+1.6a	50
d	Fructose bis-phosphate aldolase A	−1.55b/−1.54b	27–32
e	Glyceraldheyde-3 phosphate dehydrogenase	−1.75b/−1.83b	39; 44–48
f	Pyridoxal phosphate phosphatase	+2.80a/+4.42a	55
g	β-actin	−1.75b/−3.59b	33
h	Cystatin B	+2.22a/+3.12a	70
1	Ubiquitin carboxy-terminal Hydrolase L1	+3.18a/+3.31a	34–39
2	T-complex protein 1 subunit γ	+3.28a/+3,27a	60; 61
3	Δ(3,5)- Δ(2,4)-dienoyl CoA isomerase	−1.46b/−2.19b	67
4	L-isoaspartyl/D-aspartyl O-methyl transferase	−2.05b/−1.95b	41; 42
5	Coproporphyrinogen oxidase	+1.06a/−1.64b	71
6	Heterogeneous nuclear ribonucleoprotein A1	−1.43b/+1.49a	72
7	T-complex protein 1subunit ε	−2.88b/−6.54b	62
8	Density-regulated protein	−2.22b/−6.39b	–
9	Elongation factor 1 δ	−3.25b/−3.02b	63
10	Complex intermediate-associated protein 30	−3.03b/−2.61b	–
11	Alcohol dehydrogenaseNADP	+1.18a/−2.57b	51–54
12	Phosphoglicerate kinase 1	−1.39b/−2.27b	27–32
13	Voltage-dependent anion-selective channel protein 1	−1.40b/−1.74b	78–80

Reference numbers refer to reports previously published describing alterations of these proteins in different neurodegenerative diseases.

^ap>0.05; ^bp<0.05.