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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Bioorg Med Chem. 2014 Sep 16;22(21):5924–5934. doi: 10.1016/j.bmc.2014.09.015

Figure 6.

Figure 6

Structure of wild-type E. coli DHFR (PBD entry 1RX6), with Trp22 shown in blue, Trp30 in orange and Trp47 in cyan. The substrate tetrahydrofolate is shown in green and the cofactor NADPH is shown in red.