Table 6.
Multivariate Analysis for the baseline predictors of outer retinal tubulation (ORT) in any area at Week 104 (N=347)
| Baseline features | N† | Univariate analysis | Multivariate analysis§ | |||
|---|---|---|---|---|---|---|
|
|
||||||
| ORT (%) | OR (95% CI) | P value* | OR (95% CI) | P value** | ||
| Diabetes | ||||||
| No | 283 | 58 (20.5%) | 1.00 | 0.012 | 1.00 | 0.004 |
| Yes | 64 | 4 (6.25%) | 0.26 (0.09, 0.74) | 0.17(0.05,0.56) | ||
| Blocked fluorescence | ||||||
| No | 300 | 49 (16.3%) | 1.00 | 0.063 | 1.00 | 0.03 |
| Yes | 47 | 13 (27.7%) | 1.96 (0.96, 3.98) | 2.62(1.12,6.13) | ||
| Geographic atrophy in study eye | ||||||
| None/questionable | 325 | 52 (16.0%) | 1.00 | 0.001 | 1.00 | 0.0007 |
| Present | 22 | 10 (45.5%) | 4.38 (1.80, 10.7) | 7.01(2.27,21.7) | ||
| Baseline total area of CNV lesion (DA) | ||||||
| <=1 | 117 | 12 (10.3%) | 1.00 | 0.029 | 1.00 | 0.01 |
| >1 to <=2 | 79 | 14 (17.7%) | 1.89(0.82, 4.33) | 1.97(0.75,5.15) | ||
| >2 to <=4 | 82 | 17 (20.7%) | 2.29 (1.03, 5.10) | 2.75(1.09,6.95) | ||
| >4 | 69 | 19 (27.5%) | 3.33 (1.50, 7.38) | 4.62(1.82,11.7) | ||
| Baseline VA in study eye | ||||||
| 20/25–40 | 133 | 13 (9.77%) | 1.00 | 0.0002 | 1.00 | 0.003 |
| 20/50–80 | 126 | 20 (15.9%) | 1.74 (0.83, 3.67) | 1.38(0.61,3.10) | ||
| 20/100–160 | 67 | 20 (29.9%) | 3.93 (1.81, 8.53) | 3.22(1.36,7.63) | ||
| 20/200–320 | 21 | 9 (42.9%) | 6.92 (2.46, 19.5) | 6.52(1.92,22.1) | ||
| Subretinal hyper-reflective material | ||||||
| No | 84 | 7 (8.33%) | 1.00 | 0.012 | 1.00 | 0.047 |
| Yes | 263 | 55 (20.9%) | 2.91 (1.27, 6.66) | 2.50(1.01,6.17) | ||
| Drug | ||||||
| Lucentis | 175 | 25 (14.3%) | 1.00 | 0.08 | 1.00 | 0.08 |
| Avastin | 172 | 37 (21.5%) | 1.64 (0.94, 2.87) | 1.75(0.94,3.27) | ||
| Regimen | ||||||
| Monthly | 74 | 10 (13.5%) | 1.00 | 0.43 | 1.00 | 0.40 |
| Switched | 94 | 20 (21.3%) | 1.73 (0.75, 3.96) | 1.90(0.74,4.89) | ||
| PRN | 179 | 32 (17.9%) | 1.39 (0.65, 3.00) | 1.36(0.58,3.18) | ||
P values are from univariate logistic regression
P values are from multivariate logistic regression
The initial multivariate model includes diabetes, dietary supplement use, blocked fluorescence lesion, fibrotic or non-fibrotic scar, lesion type, hemorrhage contiguous with lesion (yes/no), geographic atrophy, baseline total area of CNV lesion (DA), baseline VA in study eye, subretinal tissue complex thickness in the foveal center, intraretinal fluid, SHRM, drug and regimen.
347 patients were included in the final multivariate model, 21 patients were excluded due to missing data in any of the baseline predictors in the final model.
VA=visual acuity; DA=disc area.