Table 7.
Comparison of Week 104 outcomes between patients with and without outer retinal tubulation (ORT) at Week 104 (N=368)
| Week 104 Outcomes | With ORT (N=64) | Without ORT (N=304) | P Value* |
|---|---|---|---|
| VA categories | <0.0001 | ||
| 20/200 or worse | 13 (20.3%) | 15 (4.9%) | |
| 20/50 – 20/160 | 22 (34.4%) | 90 (29.6%) | |
| 20/12 – 20/40 | 29 (45.3%) | 199 (65.5%) | |
| Mean VA in letters (SE) | 58.5 (3.11) | 68.8 (0.97) | <0.0001 |
| Mean VA change from baseline in letters (SE) | 3.69 (2.81) | 6.15 (0.94) | 0.31 |
| ≥ 15 letters increase from baseline (%) | 20 (31.3%) | 87 (28.6%) | 0.65 |
| Mean number of injections in Year 1 in PRN Groups (SE) † | 12.8 (1.03) | 13.7 (0.51) | 0.43 |
| Retinal thickness in microns, n (%) | 0.03 | ||
| <120 microns | 23 (35.9%) | 77 (25.4%) | |
| 120–212 microns | 30 (46.1%) | 194 (64.0%) | |
| >212 microns | 11 (17.2%) | 32 (10.6%) | |
| Mean change of total foveal thickness from baseline in microns (SE) | −168 (25.2) | −162 (11.0) | 0.83 |
| Intraretinal fluid, n (%) | 59 (92.2%) | 139 (45.7%) | <0.0001 |
| Subretinal fluid, n(%) | 25 (39.1%) | 121 (39.8%) | 1.00 |
| Sub-RPE fluid, n (%) | 25 (39.1%) | 109 (36.1%) | 0.67 |
| Leakage on angiography, n (%) | 18 (28.6%) | 83 (27.9%) | 0.88 |
| Mean lesion size at 2 years, disc areas (SE) | 4.47 (0.45) | 3.10 (0.18) | 0.002 |
| Mean change in lesion size from baseline, disc areas (SE) | 0.70 (0.29) | 0.68 (0.15) | 0.95 |
| Fibrotic scar, anywhere, n (%) | 31 (48.4%) | 68 (22.4%) | <0.0001 |
| Non-fibrotic scar, anywhere, n (%) | 12 (18.8%) | 52 (17.1%) | 0.72 |
| Geographic atrophy, anywhere, n (%) | 11 (17.2%) | 58 (19.1%) | 0.86 |
| Pathology in fovea center, n (%) | 0.03 | ||
| No pathology | 9 (14.1%) | 70 (23.0%) | |
| Fluid only | 0 (0%) | 13 (4.3%) | |
| Choroidal neovascularization | 7 (10.9%) | 55 (18.1%) | |
| Serous pigment epithelial detachment | 0 (0%) | 2 (0.7%) | |
| Scar | 27 (42.2%) | 59 (19.4%) | |
| Geographic atrophy | 3 (4.7%) | 11 (3.6%) | |
| Non-geographic atrophy | 14 (21.9%) | 58 (19.1%) | |
| Hemorrhage | 0 (0%) | 3 (1.0%) | |
| Retinal pigment epithelium tear | 0 (0%) | 5 (1.6%) | |
| Blocked fluorescence | 0 (0%) | 9 (3.0%) | |
| Other | 3 (4.7%) | 10 (3.3%) | |
| Unknown | 1 (1.6%) | 9 (3.0%) |
*
From Fisher exact test for comparison of proportions, and two group t-test for comparison of means.
†
Only patients in PRN group were included in the analysis
VA=visual acuity; SE=sphericalequivalent; OCT=optical coherence tomography.