Table.

Observations from OPN transgenic mice

Mouse model	Transgenic mice	Source of OPN	Apoptosis	Fibrosis	LV function	Ref
MI	OPN−/−	Interstitium/nonmyocytes	↔	↓	↓	(Trueblood et al., 2001)
Ang II infusion	OPN−/−	Interstitium	↓	↓	↓	(Matsui, et al., 2004)
Aldosteron e infusion	OPN−/−	ND	↓	↓	↓	(Sam, et al., 2004)
DOX treatment	OPN−/−	ND	ND	↓	ND	(Schunke et al., 2013)
Pressure Overload	OPN−/−	LV lysates	↔	↔	↓ hypertrophic response	(Xie et al., 2004)
I/R (repetitive)	OPN−/−	Myocytes	ND (↓ wall thickness)	↔	↓	(Duerr, et al., 2014)
Diabetes	OPN−/−	Myocytes	↓ (myocytes)	↓	↑	(Subramanian et al., 2007)
O/E	Myocyte- specific expression	Myocytes	↑ (myocytes)	↑	↓	(Renault et al., 2010; Dalal, et al., 2014)

MI, myocardial infarction; Ang II, angiotensin II, Dox, doxorubicin; I/R, ischemia/reperfusion; O/E, mice overexpressing OPN in the heart; ND, not determined