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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Neurobiol Aging. 2014 Jun 17;35(12):2701–2712. doi: 10.1016/j.neurobiolaging.2014.06.012

Figure 2.

Figure 2

EHT prevents the reference memory impairment in rats expressing I2-N/C when tested by the hippocampal-dependent spatial memory water maze test. A) Hippocampal functioning in I2-N/C rats displayed significantly faster swim speed than other groups (ANOVA, <p=0.01; Fisher’s post-hoc test, p<0.05), therefore, results of the training phase were analyzed as distance covered to reach the submerged platform. B) Water-maze task: training phase. I2-N/C rats treated with vehicle displayed delayed training performance compared to other groups (ANOVA, p=0.038; Fisher’s post-hoc test, p<0.046) reflecting hippocampal impairment that can be prevented with 6-months treatment with EHT. C) Water-maze task: Probe-trial. I2-N/C rats treated with vehicle visited less the platform location than other groups (Student t-test, p=0.023), confirming hippocampal impairment and its prevention by 6-months treatment with EHT.