Figure 3.
EHT prevents the cognitive impairment in rats expressing I2-N/C. Hippocampal functioning was measured to determine cognitive impairment. A) Object location task: sample phase. No differences were found among the groups, indicating no preferences for objects or location (Student t-test, p>0.99). B) Object location task: test phase. I2-N/C rats spent significantly less time to analyze the object in the new location (Student t-test, p<0.02), indicating cognitive impairment. When treated with EHT for 12 months I2-N/C rats displayed similar performance as control groups.