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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Trends Cell Biol. 2014 Sep 10;24(11):703–711. doi: 10.1016/j.tcb.2014.08.003

Figure 1.

Figure 1

Structure and organization of architectural protein binding sites (APBS) in yeast, Drosophila and mammals. Each DNA-binding architectural protein interacts with a particular sequence motif in the genome. For example the TFIIIC protein interacts with the B-box sequence in tRNA genes or ETC sites. DNA-binding architectural proteins require interaction with accessory proteins to accomplish their function. For example, CTCF often interacts with Cohesin, whereas in Drosophila dCTCF, BEAF and Su(Hw) interact with Mod(mdg4) and CP190. High occupancy binding sites are dense clusters of architectural proteins present at specific genomic regions and have been found in both Drosophila and mammals.