Table 2.

Fold change in T80 and τ induced by FCCP/Oligo

	T80				Shoulder Level
Depolarization	0.5s		1.3s		0.5s		1.3s		Combined
Agent	Vehicle	FCCP/ Oligo	Vehicle	FCCP/ Oligo	Vehicle	FCCP/ Oligo	Vehicle	FCCP/ Oligo	Vehicle	FCCP/Oligo
Group	C	C	C	C	C	C	C	C	C	C	L4	L5
n	61	44	66	44	3	7	19	5	22	9	9	4
Median	1.39	1.32	1.33	1.78	1.73	1.26	1.06	2.27	1.06	1.51	2.79	0.77
IQR	1.01–1.98	0.88–2.46	1.07–1.91	1.00–8.09	0.05–2.69	0.96–2.33	0.86–1.33	1.00–7.24	0.85–1.36	0.91–2.54	2.32–9.55	0.55–1.46
1-sample Wilcoxon	<0.001	0.002	<0.001	<0.001	0.75	0.109	0.251	0.125	0.206	0.027
Vehicle vs. FCCP/Oligo	0.647		0.105		0.500		0.044		0.042
Group Main Effect										0.009
Paired Comparisons										L4 vs. L5*

Measured parameters include the transient duration measured as the time for 80% recovery back to baseline from the peak, and the [Ca²⁺]_c level of the shoulder during the recovery phase of transients produced by depolarization with K⁺ of either 0.5s or 1.3s duration. Agents included either vehicle or FCCP 1μM combined with oligomycin 10μM (FCCP/Oligo). Groups included Control (C), and neurons from the 4^th lumbar (L4) and L5 dorsal root ganglia after spinal nerve ligation. n is the number of neurons. The median and interquartile range (IQR) are shown for the fold change of the measured parameter produced by FCCP/Oligo application, calculated as the ratio of the second depolarization (following FCCP/Oligo) divided by the first depolarization (baseline) for each neuron. 1-sample Wilcoxon is the P of an effect of vehicle or FCCP/Oligo in that group using a one-sample Wilcoxon test (compared to a value of 1). Vehicle vs. FCCP/Oligo is the P for the comparison of vehicle vs. FCCP/Oligo in control neurons using Mann-Whitney test. Group Main Effect P is the probability of a main effect comparing the three groups (C, L4, L5) during FCCP/Oligo application, using Kruskal-Wallis. Paired Comparisons gives the P for significant paired comparisons between these groups (blank when none) using Dunn’s test.

^*P < 0.05.