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Pros and Cons for inhibiting VEGF signaling
| Pros | Cons |
|---|---|
| Orders retinal angiogenesis | Reduces serum VEGF in infants |
| Preclinical studies showing effects in models of oxygen-induced retinopathy | Recurrent NV in preterm infants often much later than after laser |
| Survival factor in adult homeostasis and in developing vascular and neural beds | |
| Animal models show reduced body weight gain, loss of retinal capillary support, cell death in photoreceptors, reduced serum VEGF, recurrent IVNV |
