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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2014 Sep 28;22(22):6409–6421. doi: 10.1016/j.bmc.2014.09.043

Scheme 4.

Scheme 4

Convergent syntheses of 25a–h, j, l–r, t, v–x. Reagents and conditions: (i) TMS diazomethane, CH2Cl2, MeOH, 81%; (ii) Oxalyl chloride, CH2Cl2, 3h, 0–30°C; (iii) Amines, Hunig’s base, CH2Cl2, 8h, 23–86%; (iv) 2-aminopyridine, Hunig’s base, CH2Cl2, 8h, 23–30%.