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. Author manuscript; available in PMC: 2015 Nov 10.
Published in final edited form as: Cancer Cell. 2014 Oct 30;26(5):695–706. doi: 10.1016/j.ccell.2014.09.009

Figure 4. Phenotypic analysis identifies the PLP+ cells of origin as embryonic Schwann cell precursors.

Figure 4

(A) DNSCs obtained from E13.5 PlpCre-ERT;Nf1flox/flox;R26R-YFP embryos, whose mother was administered with tamoxifen at E11.5, were stained for YFP, DAPI and lineage markers: Nestin (a), P75 (b), BLBP (c), GFAP(d), S100β (e), βIII-tubulin (f) and GAP43 (g – i).

(B) Formalin fixed paraffin embedded sections from E13.5 PlpCre-ERT;Nf1flox/flox;R26R-YFP embryos, whose mother was administered with tamoxifen at E11.5, were stained for YFP, DAPI and lineage markers: GAP43 (a– c), Nestin (d), P75 (e), BLBP (f), βIII-tubulin (g), GFAP (h) and S100β (i). DRG=dorsal root ganglia, NR= nerve root, PN=peripheral nerve, SC=spinal cord.

Scale bars: 50 μm for all.

See also Figure S3.