Table 1. Displacement of 5 nM of (E,E)-1-[3H]-2,5-bis(4’-hydroxy-3’-carbomethoxystyryl)benzene (1a) from synthetic Aβ fibrils by unlabeled compounds.
Compound | Aβ(1–40) EC50, µM |
Aβ(1–42) EC50, µM |
---|---|---|
Chrysamine G | 9 | 0.9 |
Congo Red | 2.3 | 0.7 |
1b or X-34 | 0.53 | 0.2 |
BSB | 0.23 | 0.12 |
ISB | 0.2 | 0.15 |
K114 | >10 | 3 |
BMB | >10 | 3 |
PIB | >10 | >10 |
BTA-1 | >10 | >10 |
IMPY | >10 | >10 |
ThT | >10 | >10 |
ThS | >10 | >10 |
primulin | >10 | >10 |
curcumin | >10 | 4 |
resveratrol | >10 | >10 |
resorufin | >10 | >10 |
naproxen | >10 | >10 |
ibuprofen | >10 | >10 |