Table 1. Displacement of 5 nM of (E,E)-1-[3H]-2,5-bis(4’-hydroxy-3’-carbomethoxystyryl)benzene (1a) from synthetic Aβ fibrils by unlabeled compounds.
[3H]-X-34 is another name for (E,E)-1-[3H]-2,5-bis(4’-hydroxy-3’-carbomethoxystyryl)benzene (1a); X-34 is another name for (E,E)-2,5-bis(4’-hydroxy-3’-carbomethoxystyryl)benzene (1b); BSB, (E,E)-1-bromo-2,5-bis(4’-hydroxy-3’-carbomethoxystyryl)benzene; ISB, (E,E)-1-iodo-2,5-bis(4’-hydroxy-3’-carbomethoxystyryl)benzene; K114, (E,E)-1-bromo-2,5-bis(4’-hydroxystyryl)benzene; BMB, (E,E)-1-methoxy-2,5-bis(4’-aminostyryl)benzene or as it also known 1,4-bis(4-aminophenylethenyl)-2-methoxybenzene; PIB, Pittsburgh Compound B; BTA-1, 2-(4´-methylaminophenyl)benzothiazole; IMPY, 2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine; ThT, Thioflavine T; ThS, Thioflavin S.
| Compound | Aβ(1–40) EC50, µM |
Aβ(1–42) EC50, µM |
|---|---|---|
| Chrysamine G | 9 | 0.9 |
| Congo Red | 2.3 | 0.7 |
| 1b or X-34 | 0.53 | 0.2 |
| BSB | 0.23 | 0.12 |
| ISB | 0.2 | 0.15 |
| K114 | >10 | 3 |
| BMB | >10 | 3 |
| PIB | >10 | >10 |
| BTA-1 | >10 | >10 |
| IMPY | >10 | >10 |
| ThT | >10 | >10 |
| ThS | >10 | >10 |
| primulin | >10 | >10 |
| curcumin | >10 | 4 |
| resveratrol | >10 | >10 |
| resorufin | >10 | >10 |
| naproxen | >10 | >10 |
| ibuprofen | >10 | >10 |