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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2014 Oct 2;22(22):6387–6391. doi: 10.1016/j.bmc.2014.09.050

Figure 1.

Figure 1

Chemical structures of the BC1 scaffold and BODIPY-FL-labeled analogs. R1 is the adduct of hydrazine-functionalized BODIPY-FL, and R2 is the adduct of maleimide-functionalized BODIPY-FL. Fluorescein-labeled peptides were also prepared and tested to rule out dye-dependent effects on cell uptake. HT1-Neut and HT1-Neg are head-to-tail cyclic analogs of BC1-Neut and BC1-Neg, and Lin-Neut and Lin-Neg are linear analogs of BC1-Neut and BC1-Neg. See Supplementary Information for complete structural and synthesis details.