Table 1.
Prodrug | t90 (pH 5.0) | t1/2 (pH 7.4) | t1/2 (50% HP) |
---|---|---|---|
6a | 9.9 ± 0.5 h | no data | no data |
6b | 5.2 ± 0.2 d | 0.48 ± 0.03 d | 0.76 ± 0.03 d |
6c | 0.9 ± 0.0 d | no data | no data |
6d | 14 d | 0.9 ± 0.0 d | 1.3 ± 0.1 d |
6e | 5.6 ± 0.5 d | 0.5 ± 0.2 d | 2.2 ± 0.1 h |
6f | 5.2 ± 0.7 h | no data | no data |