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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Oct 2;24(22):5212–5215. doi: 10.1016/j.bmcl.2014.09.072

Table 1.

In vitro stability of prodrugs 6a-f in buffers and in 50% human plasma (HP).

Prodrug t90 (pH 5.0) t1/2 (pH 7.4) t1/2 (50% HP)
6a 9.9 ± 0.5 h no data no data
6b 5.2 ± 0.2 d 0.48 ± 0.03 d 0.76 ± 0.03 d
6c 0.9 ± 0.0 d no data no data
6d 14 d 0.9 ± 0.0 d 1.3 ± 0.1 d
6e 5.6 ± 0.5 d 0.5 ± 0.2 d 2.2 ± 0.1 h
6f 5.2 ± 0.7 h no data no data