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. Author manuscript; available in PMC: 2014 Dec 4.
Published in final edited form as: Biol Syst Open Access. 2013 Dec 16;2:1000123. doi: 10.4172/2329-6577.1000123

Figure 1.

Figure 1

Schematic diagram of the physiological based pharmacokinetic model for BMP2 in mice. The ten compartments are modeled as continuous stirred tank reactors, and have uniform concentrations. These organs are characterized by their concentration of BMP2 (c), BMP2 turnover (PT), blood flow rates (Q) and the concentration of BMPRIa. The tissue compartments are numbered from #1 (brain) to #9 (fat) with #10 being blood.