Table III.
Correlation of ASS expression in cancer cells and the tumor/normal ratio of ASS expression with histopathological data of patients with gastric cancer.
| ASS expressiona in cancer cells (n=35) | Tumor/normal ratio of ASS expressiona (n=35) | |||
|---|---|---|---|---|
|
|
|
|||
| Characteristics | Median (range) | P-value | Median (range) | P-value |
| All patients | 0.65 (0.73)b 0.39 (0.02–3.74)c |
1.13 (0.74)b 1.01 (0.38–3.79)c |
||
| Gender | 0.459 | 0.699 | ||
| Female | 0.32 (0.11–1.36) | 1.02 (0.38–2.61) | ||
| Male | 0.50 (0.02–3.74) | 1.01 (0.47–3.79) | ||
| Histological differentiation | 0.791 | 0.274 | ||
| Well or moderate | 0.50 (0.02–3.74) | 1.03 (0.42–3.79) | ||
| Poor | 0.34 (0.06–1.72) | 0.97 (0.37–1.65) | ||
| WHO classification | 0.856 | 0.570 | ||
| Tubular | 0.50 (0.02–3.74) | 1.03 (0.42–3.79) | ||
| Mucinous | 0.30 | 0.76 | ||
| Poorly-differentiated | 0.35 (0.06–1.72) | 1.08 (0.48–1.65) | ||
| Signet-ring cell | 0.32 (0.28–0.54) | 0.73 (0.38–1.17) | ||
| Lauren’s classification | 0.471 | 0.724 | ||
| Intestinal | 0.48 (0.02–3.74) | 1.02 (0.42–3.79) | ||
| Diffuse | 0.33 (0.06–0.70) | 1.11 (0.52–1.65) | ||
| Mixed | 0.50 (0.30–1.36) | 0.85 (0.38–3.01) | ||
| Borrmann’s classification (type) | 0.401 | 0.882 | ||
| I | 1.31 (0.50–2.12) | 2.24 (0.69–3.79) | ||
| II | 0.32 (0.02–3.74) | 1.04 (0.42–1.68) | ||
| III | 0.35 (0.08–1.72) | 1.01 (0.38–3.01) | ||
| IV | 0.89 (0.06–1.36) | 1.01 (0.53–2.61) | ||
| Lymph node metastasis | 0.907 | 0.815 | ||
| Negative | 0.32 (0.06–3.74) | 0.94 (0.38–3.79) | ||
| Positive | 0.42 (0.02–1.72) | 1.02 (0.47–3.01) | ||
| Depth of invasion | 0.747 | 0.396 | ||
| Lamina propria (T1a) | 0.32 (0.30–0.33) | 0.72 (0.50–0.94) | ||
| Submucosa (T1b) | 0.50 (0.31–3.74) | 0.69 (0.38–1.37) | ||
| Muscularis propria (T2) | 0.91 (0.02–1.41) | 0.79 (0.47–1.72) | ||
| Subserosa (T3) | 0.40 (0.08–2.12) | 1.24 (0.48–3.79) | ||
| Serosa (T4a) | 0.39 (0.21–1.72) | 1.01 (0.52–1.40) | ||
| Adjacent organ (T4b) | 0.26 (0.06–1.24) | 0.94 (0.53–2.61) | ||
| Lymphovascular tumor emboli | 0.970 | 0.924 | ||
| Negative | 0.32 (0.06–3.74) | 0.94 (0.42–3.79) | ||
| Positive | 0.42 (0.02–1.41) | 1.02 (0.38–2.61) | ||
a
Expression of ASS protein is presented as the ratio of the expression of ASS to that of β-actin, as determined by western blotting.
b
Data presented are the mean (SD).
c
Data presented are the median (range).
ASS, argininosuccinate synthetase; WHO, World Health Organization; n, number; SD, standard deviation.