Table 1.

Trial Entry Criteria.

Inclusion Criteria

Age > 18 years Hospitalization for acute HF (either systolic HF or HF with preserved ejection fraction) or within 2 weeks of discharge of a hospitalization for acute HF Dyspnea at rest or minimal exertion plus at least 1 sign of volume overload (JVP greater than 10 cm, peripheral edema, congestion on chest x-ray) Previous HF hospitalization within the past 1 year ESCAPE risk score ≥4 indicating >50% predicted 6-month mortality Anticipated discharge from hospital with anticipated ability to return to outpatient follow-up appointments

OR

Subjects >18 years of age, hospitalized with acute HF with signs/symptoms of volume overload who do not meet all other eligibility criteria may also be considered for enrollment if they can be categorized into one of the following high risk groups: Support with chronic inotropes without plans for cardiac transplant or cardiac assist device and anticipated discharge from hospital Multiple hospitalizations for HF in the past 12 months (minimum 3) and anticipated discharge from hospital No prior hospitalization for HF in the past 12 months but with an ESCAPE score > 4 and anticipated discharge from hospital

Exclusion Criteria

Acute coronary syndrome within 30 days Cardiac resynchronization therapy within the past 3 months or current plan to implant Active myocarditis, constrictive pericarditis Severe stenotic valvular disease amendable to surgical intervention Anticipated heart transplant or ventricular assist device within 6 months Renal replacement therapy Non-cardiac terminal illness Women who are pregnant or planning to become pregnant Inability to comply with study protocol