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Schematic representation of (A) intracellular and (B–D) extracellular function of gal-3. A. Nuclear gal-3 is apoptotic, while cytoplasmic gal-3 is shown anti-apoptotic. B. Gal-3 promotes tumor-endothelial cell interactions. C. Gal-3 promotes apoptosis of T-cells. D. Gal-3 promotes tumor cell angiogenesis.
