Table 2.

Age-standardized fracture incidence rates (per 100,000 person-years) since the initiation of bisphosphonate treatment according to medication possession ratio (MPR)

	Intertrochanteric/femoral neck fractures			Subtrochanteric/femoral Shaft fractures
	MPR<1/3	MPR 1/3–<2/3	MPR ≥2/3	MPR<1/3	MPR 1/3–<2/3	MPR ≥2/3
#Cases
Year 1	813	598	1307	72	53	130
Year 2	1341	592	1016	99	54	123
Year 3	1122	466	645	84	52	106
Year 4	671	293	325	47	36	64
Year 5	162	80	90	<11	14	<11
Rate(95 % CI)
Year 1	498.8(465.1–534.4)	650.6(599.5–704.9)	566.2(535.9–597.8)	44.1(34.5–55.5)	57.6(43.2–75.4)	56.3(47.0–66.9)
Year 2	937.5(888.0–989.1)	797.1(734.2–864.0)	722.8(679.0–768.7)	69.4(56.4–84.5)	72.2(54.2–94.2)	87.9(73.1–105.0)
Year 3	1072.2(1010.4–1136.9)	941.9(858.2–1031.7)	799.4(738.8–864.7)	80.5(64.2–99.7)	104.5(78.0–137.1)	131.1(107.3–158.7)
Year 4	1085.2(1004.5–1170.8)	980.2(870.6–1099.9)	773.3(691.1–862.8)	76.5(56.1–101.8)	117.8(82.4–163.5)	152.7(117.5–195.4)
Year 5	1166.0(992.3–1361.6)	1020.7(807.7–1273.1)	892.4(715.8–1100.3)	73.1(34.8–135.2)	172.3(93.7–291.8)	na
P value
Year 1	ref	<0.001	0.0046	ref	0.14	0.09
Year 2	ref	0.001	<0.001	ref	0.82	0.08
Year 3	ref	0.02	<0.001	ref	0.14	0.0009
Year 4	ref	0.15	<0.001	ref	0.05	0.0003
Year 5	ref	0.33	0.04	ref	0.04	na
P values
Year 1		ref	0.0049		ref	0.88
Year 2		ref	0.06		ref	0.22
Year 3		ref	0.007		ref	0.18
Year 4		ref	0.003		ref	0.21
Year 5		ref	0.39		ref	na