Table 4.
Global Conformation States as a Function of the Chemical State of the β-Site and Ligand-Bound Species Along the Tryptophan Synthase αβ-Reaction Pathway
| Substrate | Global Conformation States | |||
|---|---|---|---|---|
| Stage I | ||||
| α*βC(Ain) | α*βC(Ain) | α*βO(Ain) | α*βO(Ain) | |
| L-Ser | ||||
| αOβC(GD1) | αCβC(GD1) | αCβO(GD1) | αOβO(GD1) | |
| αOβC(Aex1) | αCβC(Aex1) | αCβO(Aex1) | αOβO(Aex1) | |
| αOβC(Q1) | αCβC(Q1) | αCβO(Q1) | αOβO(Q1) | |
| α O β C (A-A) | αCβC(A-A) | αCβO(A-A) | αOβO(A-A) | |
| Stage II | ||||
| IGP | ||||
| (IGP)αOβC(A-A) | (IGP)αC βC (A-A) | (IGP)αCβO(A-A) | (IGP)αOβO(A-A) | |
| (G3P)αOβC(A-A)(Indole) | (G3P)αC βC (A-A)(Indole) | (G3P)αCβO(A-A)(Indole) | (G3P)αOβO(A-A)(Indole) | |
| (G3P)αOβC(Q2/3) | (G3P)αC βC (Q2/3) | (G3P)αCβO(Q2/3) | (G3P)αOβO(Q2/3) | |
| (G3P)αOβC(Aex2) | (G3P)αC βC (Aex2) | (G3P)αCβO(Aex2) | (G3P)αOβO(Aex2) | |
| G3P | αOβC(Aex2) | αCβC(Aex2) | αC βO(Aex2) | αOβO(Aex2) |
| αOβC(GD2) | αCβC(GD2) | αCβO(GD2) | αOβO(GD2) | |
| L-Trp | α*βC(Ain) | α*βC(Ain) | α*βO(Ain) | α*βO(Ain) |